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How Fructose Destroys People With Type 2 Diabetes

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  • How Fructose Destroys People With Type 2 Diabetes

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    The information I will share today is valuable not only for type 2 diabetics but also for those with fatty liver. And also for those who are more or less healthy, but have 5-10 extra pounds, which they are going to get rid of.

    At first glance, fructose may seem like a tempting alternative to regular table sugar for type 2 diabetes. It is a couple of times sweeter than regular sugar and has a low glycemic index!

    Therefore, it seems ideal to "kill two birds with one stone": successfully control blood sugar and do not offend a sweet tooth.

    But, as clinical and life practice shows, this approach is superficial and flawed. Because it does not take into account some of the metabolic characteristics of fructose.






    What is fructose?

    First, a little theoretical basis! Fructose is one of the simplest sugars (oligosaccharides). It can be found exclusively in many fruits. Therefore, it is also called fruit sugar. It is not found in animal food at all.

    It is also found in regular table sugar.




    The role of fructose in metabolism

    This carbohydrate does not have any specific and critical functions in the body. We can do without it in food because the body is able to create it. Let's compare fructose with glucose.

    The latter is our “native” blood sugar. All cells of the body can feed on it. Not so with fructose. No body tissue can directly feed on fructose, with a few minor exceptions. When a substance enters the body, with which it cannot do anything, then the liver turns on.

    100% of the fructose entering the body is metabolized by the liver. The liver decides its further fate, based on the state in which the body is now.

    Under normal conditions, the liver can “painlessly” metabolize 50 grams of fructose per day. It will make glucose out of it. Part of which will be sent to the blood and the other will be deposited in its own glycogen stores.

    What does “normal conditions” mean in this context?

    This is when a person has a stable diet, he/she does not lose or gain weight. At the same time, a person has normal blood sugar and almost full stores of sugar in the form of muscle and liver glycogen.


    The amount of fructose over 50 grams will be sent in the long term. This means the liver will make fat out of it. That is, the process of creating its own saturated fat is activated.


    This process is triggered whenever the body receives unnecessary carbohydrates.

    Then, the liver will send part of this fat into the bloodstream and in the blood test it will be seen by triglycerides. The rest is stored in the liver itself.

    This process has no limit. All excess fructose will be converted to fat.






    Why fructose burns a person from the inside

    All carbohydrates have a damaging effect on blood and blood vessels.


    Therefore, the body makes sure that the concentration of blood sugar does not exceed the maximum that the antioxidant systems and the glycocalyx (the protective layer on the vessels) can handle.


    That's what insulin is for! It has to hide excess sugar from the blood and blood vessels in the cells in time so that it does not do bad things.

    The bottom line is that carbohydrates try to "stick" to everything they touch. They permeate any free molecule or substance.

    This is called glycation and is accompanied by severe oxidative stress that damages all surrounding structures.

    An example of the end result of this process is glycated hemoglobin. This is hemoglobin, to which sugar has irreversibly adhered. In the analysis, it is also called HbA1c.

    This sugar-burned protein is one example of advanced glycation end products (AGEs). They are just formed as a result of blood sugar "soaking" everything.


    This is a normal process and there are mechanisms to control it. In general, glycation in the blood directly increases the overall level of inflammation in the body.


    Therefore, insulin resistance and high blood sugar are so closely associated with the development of 95% of non-communicable diseases.






    But what does fructose have to do with it?

    If we take the ability of glucose (original blood sugar) to glycate as x1, then the ability of fructose to glycate exceeds x10. It is more than 10 times eager to react with its environment.

    Therefore, the toxicity of fructose to the contents of blood vessels starts at very low concentrations.

    And the body knows it!


    Therefore, it does not allow fructose to move freely through the blood. It tends to keep its concentration below 1% of the glucose concentration.


    So, fructose, after being absorbed from the digestive system, is not immediately sent to the general bloodstream.

    First, the body sends it to the liver so that it takes the brunt of the blow and neutralizes the excess. It does not release it from itself in its pure form but processes it either into glucose or into fats.






    The harm of fructose with excess weight and type 2 diabetes

    We remember that under normal conditions, about 50 grams of fructose is tolerated by a healthy body without problems. But being overweight and insulin resistance (diabetes) are far from common conditions, in not the healthiest body.

    Both overweight and diabetes have similarities. For example, insulin in the blood is increased more than necessary. The blood is full of sugar.

    The stores of glycogen in the muscles in the liver are filled to the limit. Indeed, fructose will not raise blood sugar significantly, but this trait has 0 benefits against the background described.


    Fructose, which will enter the body (and then the liver), against this background, will be all converted into fats.


    Because there is no longer room for sugar in the body. Where it leads:
    • A high concentration of fat in the blood. In a blood test, these are elevated triglycerides. High triglycerides are a strong risk factor for premature death from any cause.
    • Fatty liver. This is a non-alcoholic fatty liver disease - steatohepatosis. Against the background of insulin resistance, fructose may become its main cause.
    • Increased uric acid. Fructose metabolism is a very intensive process, therefore it increases the concentration of uric acid. By this, fructose contributes to the development of gouty arthritis, as well as essential hypertension.




    Diabetes as a business

    Diabetes is a powerful brand and a lucrative market. And among the related products, there are not only glucometers but also sweets with sweeteners, among which we find fructose.

    In every store, you can now find a rich shelf of sweets for diabetics. The most harmful of them, just those on fructose. This is the worst case scenario.

    Other sugars and sweeteners follow. The most harmless are erythritol, xylitol, and other “-ols”. If I say that they are better than fructose, this does not mean that they are good on their own. Everything in comparison.



    It should be understood that such products do not solve the problem of diabetes and insulin resistance.


    On the contrary, they only support it, since they remain addicted to sweet taste. And this is a manifestation of overloaded carbohydrate metabolism and depressed fat metabolism. What, in essence, is type 2 diabetes.

    Type 3 diabetes and insulin resistance are normal manifestations of a high-carb lifestyle. No sugar substitution will solve the problem other than cutting carbs to an adequate minimum in your diet.






    Fructose, alcohol, and childhood

    It is interesting to compare the metabolism of fructose and ethanol. With regard to fructose, we already know that the liver is 100% occupied with it.

    The situation is similar with ethanol. 10% of alcohol is metabolized by the brain. Therefore, drunkenness occurs, that is, a banal intoxication.

    10% of alcohol is detoxified by the intestines, so alcohol is directly related to all intestinal diseases.

    The remaining 80% is metabolized by the liver. And it just so happens that the detoxification of alcohol and fructose are very similar!


    Fats are also created from alcohol and it also leads to fatty liver. Only in this case, it will be called alcoholic fatty liver disease. And alcohol also increases the concentration of uric acid in the blood.


    Are alcohol and fructose the same thing? With some differences, they are almost identical. Fructose only does not cause intoxication in the brain.

    All of its toxic load falls on the liver. Still, non-alcoholic fatty liver disease is many times more common than alcoholic fatty liver disease.






    Fructose and children

    Parents often ask about the nutrition of their children. After all, children are constantly begging for sweets. And often they are also brutally manipulated to get what they want.

    Parents justify their weakness with general phrases like “the child has a childhood!”. In my humble opinion, this interpretation of childhood is disastrous.

    Ultimately it will make one of the children a sugar addict, an unhappy fat man, or a diabetic. Obesity, diabetes, and fatty liver disease now occur between the ages of 9-10.


    The sweets that kids are so attracted to are full of sugar. And sugar is full of fructose. Now let's remember the comparison of fructose with alcohol and conduct a thought experiment.


    Are you going to let your child drink whiskey, beer, and wine? I don’t think so. But you will allow your child to throw a sugar-fructose bomb, which differs from alcohol only in that it does not cause brain intoxication.

    For some reason, you forbid your child to drink alcohol, but you do not forbid drinking sugar. And this despite the fact that the latter is more toxic to the liver than alcohol.

    So, all industrial sweets - cookies, ice cream, cakes - are just another kind of addiction for the children's segment of consumers.

    Make a choice, dear parents.






    Let's sum up

    Pure fructose is a problem for the body of any person. It doesn't make much sense to substitute it for regular table sugar. In principle, there is no any nutritional use of fructose powder and products on it in the diet.

    Other sweeteners can be used, but only as a temporary step towards eliminating industrial sweetness altogether.




    References



    https://www.ncbi.nlm.nih.gov/pmc/art...s-09-00385.pdf

    https://www.ncbi.nlm.nih.gov/pmc/art...f/an013912.pdf

    https://www.ncbi.nlm.nih.gov/pubmed/3132203

    https://www.ncbi.nlm.nih.gov/pmc/art...016-013191.pdf

    https://www.ncbi.nlm.nih.gov/pmc/art...s-10-01329.pdf

    Last edited by Rolf Pettersen; 11-16-2020, 12:43 PM.

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