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Research: Ketones Help With Heart Failure

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  • Research: Ketones Help With Heart Failure

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    Ketones are already known to be good for the brain. For example, they help people with Alzheimer's disease.

    There is reason to believe that ketones are also useful directly for the heart - in case of heart failure.





    Ketones for heart failure

    A study of patients with chronic heart failure was published in the journal Circulation of the American Heart Association (AAC).

    Note: Heart failure is the inability of the heart to pump enough blood for the body. Among the causes may be a heart attack, atrial fibrillation, and others.


    The researchers did the following:

    16 patients with chronic heart failure were randomly divided into two groups.

    One group was given intravenous beta-hydroxybutyrate (BGB), a ketone body produced by the liver on a low - carb diet (a keto diet).

    The other group was given a placebo.

    And they measured the volume of blood pumped by the heart. For this, electrocardiography and a Swan-Gantz catheter were used. PET scans measured the amount of oxygen taken up by the heart.

    Result: in those who received a dose of BGB, even at a concentration of only 0.7 mmol/liter of ketones in the blood, blood flow increased by +0.3 liters per minute.

    When the concentration of ketones in the blood was 3.3 mmol / liter, the blood flow increased by an average of +2 liters per minute.


    That is, with the help of ketones, the weakened heart was able to work more efficiently. Interestingly, ketones do not have such an effect on a healthy heart.






    A potentially new type of effective therapy

    There were few subjects, but the study was carried out qualitatively. There was an intervention, a test group, and a control group that swapped places. This confirms the effect of ketones, not other factors.

    The study authors also found that the more ketones the subjects received, the better the result.

    On Twitter, there is a comment by cardiologist Christian Assad, who confirmed the research data with observations from his practice:


    "I have 3 Heart Failure patients with phenomenal results on LowCarb + Intermittent Fasting. Going from frequent heart failure exacerbation admission to none. I believe that MCT oil, as well as exogenous ketones, could have an important role as a therapeutic application in HF."

    Christian Assad, cardiologist (original tweet).


    The authors of the study themselves concluded that 3-beta-hydroxybutyrate may potentially represent a new treatment principle for patients with heart failure and reduced ejection fraction.

    We can produce beta-hydroxybutyrate ourselves, using the keto diet or fasting. This is what this site is all about.

    If you suspect heart failure, be sure to consult with your doctors.



    You may be interested to read:



    Last edited by Alan Zalewski; 09-15-2020, 07:44 PM.

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